This was an interesting process, essentially the information to complete this task is too vast, and not easily accessible, so I could only put together a small sampling.
Essentially I wanted a simple table of all of the animal genes that have been modified.
Here’s what they returned, not a complete data-source, not verified.
Why did I do this?
Because research that permanently changes the genome of any species needs to be easily accessed by the public, we need to know who is doing this research, who is funding it, why, and the findings. Just finding a list of edited genes is rough, how would we possibly keep track of the permanent changes?
I’ll try to put something together that’s accurate, inclusive, and complete. I’ll post here as an update if I ever get around to it.
| Animal | Genetic Knockout | Transgenic | Reporter Gene Insertion | Conditional Gene Expression | Humanized Mice | Cre-lox Recombination | Fluorescent Protein Tagging | Tissue-Specific Knockout | Gene Editing (CRISPR/Cas9) | Inducible Expression Systems |
| Mice | Immune System Function, Cancer Research, Neurological Disorders, Cardiovascular Health, Metabolic Processes, Developmental Biology, Behavioral Studies, Reproductive Biology, Sensory Functions, Drug Response | Disease Models, Reporter Genes, Gene Therapy Models, Metabolic Studies, Immune System, Drug Response, Developmental Biology, Neuroscience, Cardiovascular Research, Behavioral Studies | Cell Tracking, Tumor Growth, Gene Expression Patterns, Neural Activity, Immune Response, Stem Cell Research, Drug Efficacy, Developmental Biology, Cardiovascular Studies, Metabolic Processes | Disease Modeling, Developmental Biology, Neuroscience, Cancer Research, Immunology, Metabolic Studies, Cardiovascular Research, Aging Research, Stem Cell Biology, Pharmacogenomics | Immunology, Cancer Research, Infectious Diseases, Drug Development, Genetic Disorders, Transplantation Science, Hematology, Vaccine Development, Autoimmune Diseases, Neurology | Tissue-Specific Gene Alterations, Temporal Control of Gene Expression, Cancer Research, Neuroscience, Developmental Biology, Cardiovascular Studies, Metabolic Disorders, Immunology, Aging Research, Pharmacological Studies | Cell Tracking, Protein Localization, Gene Expression, Neural Circuit Mapping, Cancer Research, Developmental Biology, Immunology, Cardiovascular Research, Stem Cell Research, Drug Delivery | Cancer Research, Neuroscience, Cardiovascular Studies, Metabolic Disorders, Immunology, Developmental Biology, Aging Research, Reproductive Biology, Musculoskeletal Research, Pharmacology | Precise Disease Modeling, Functional Genomics, Cancer Research, Genetic Disorders, Neuroscience, Immunology, Developmental Biology, Regenerative Medicine, Aging Research, Metabolic Disease Studies | Temporal Gene Function Study, Disease Modeling, Drug Testing, Cancer Research, Neuroscience, Developmental Biology, Immunology, Metabolic Research, Aging Studies, Behavioral Genetics |
| Rats | Immune System Function: CD4, CD8, Bcl-2, IL-10, TNFα, STAT1, Foxp3, etc.; Cancer Research: p53, Rb1, KRAS, APC, PTEN, Myc, Braf, etc.; Neurological Disorders: APP, Tau, SNCA, HD, SOD1, DYT1, FMR1, etc.; Cardiovascular Health: Nkx2-5, Mef2c, Tbx5, Gata4, ACE2, β-adrenergic receptor, SERCA2, etc.; Metabolic Processes: Leptin, Insulin, Adiponectin, PPARγ, UCP1, SREBP1, FASN, etc.; Developmental Biology: Hox genes, Shh, Wnt, BMP, Fgf, Notch, Pax6, etc.; Behavioral Studies: BDNF, 5-HTTLPR, COMT, OXTR, AVPR1a, MAOA, GABRA2, etc.; Reproductive Biology: FSH, LH, ERα, PR, AR, Cyp19a1, Sry, etc.; Sensory Functions: Rho, Crx, Nrl, Gnat1, Gnat2, Trp channels, Otx2, etc.; Drug Response: CYP enzymes, ABCB1, SLC transporters, Nuclear receptors, G protein-coupled receptors, Ion channels, Kinases, etc. | Insulin, GH, Factor IX, EPO, CFTR | GFP, RFP, YFP, Luciferase, Cre | Cre/loxP, Tet-On/Tet-Off, Flp/FRT, doxycycline-inducible | [Details for Rats] | loxP sites flanking genes of interest | GFP, RFP, YFP, CFP | Cre/loxP system, Tet-On/Tet-Off system | Ins2, Pparg, Lep, Cyp2d22 | Tet-On/Tet-Off, doxycycline-inducible |
| Zebrafish | Notochord genes: ntl, etc.; Immune System: Rag1/Rag2, etc.; Blood Cell Development: Gata1, etc.; Tumor Suppression: tp53, etc. | GFP, RFP, YFP, Oncogenes, Growth factors | GFP, RFP, YFP, Luciferase, Cre | Cre/loxP, Tet-On/Tet-Off, Gal4/UAS, tamoxifen-inducible | [Details for Zebrafish] | loxP sites flanking genes of interest | GFP, RFP, YFP, CFP | Gal4/UAS system, Cre/loxP system | p53, Kras, Myc, Tgfb2, Notch | Tet-On/Tet-Off, tamoxifen-inducible |
| Fly | Fruit Flies: Eyeless (ey), Wingless (wg), Dystrophin, Hedgehog (hh), etc. | GFP, Gal4, UAS, Hox genes, Oncogenes | GFP, lacZ, Gal4, UAS, Cre | Gal4/UAS, Flp/FRT, QF2/QF2, RU486-inducible | [Details for Fly] | FRT sites flanking genes of interest | GFP, RFP, YFP, CFP | Gal4/UAS system, Flp/FRT system | P53, Ras, Notch, Wnt, Hedgehog | Gal4/UAS system, RU486-inducible |
| Worm | Worms: daf-2, age-1, p53, clk-1, unc-104, etc. | GFP, RFP, YFP, Hox genes, Morphogens | GFP, RFP, YFP, Luciferase, Cre | Gal4/UAS, Cre/loxP, Flp/FRT, albendazole-inducible | [Details for Worm] | loxP sites flanking genes of interest | GFP, RFP, YFP, CFP | Gal4/UAS system, Cre/loxP system | daf-2, age-1, p53, clk-1, unc-104 | Gal4/UAS system, albendazole-inducible |